Scientific Rationale

Lyftogt Perineural Injection Treatment™ (previously known as Neural Prolotherapy) is based on sound Neuro-scientific research

Because Lyftogt P.I.T.™/ Neural Prolotherapy does not target tendons, ligaments or joints the question had to be asked what causes the often dramatic decline in pain levels after even a few treatments.

A working hypothesis was developed that glucose targets glucose sensing pain nerves called nociceptors located in nerve trunks immediately under the skin. These nerve trunks may contain up to 30,000 small fibers per mm2.  Half of these small fibers are a variety of ‘pain fibers’, technically known as sensocrine or peptidergic nociceptors. These fibers are able to sense a large range of chemical, physical and thermal impulses and respond by releasing neuropeptides or neurohormones. This hormonal or endocrine function serves tissue homeostasis or steady state. It is essential for ongoing tissue maintenance and repair. Under normal conditions the homeostatic or steady state function does not cause pain or inflammation. However when injured or irritated these peptidergic nociceptors are activated and thought to be responsible for painful conditions described as ‘neuralgias’ or ‘neuropathic pain’ or more commonly known as ‘chronic pain’. Peptidergic nociceptors are also able to detect high acid levels or acidosis and low glucose levels or glycopenia inside the nerves and respond by causing neurogenic inflammation and increased firing, perceived in the brain as neuropathic pain. Neuropathic pain is increasingly viewed as a homeostatic alarm signal indicating critically low levels of energy or glucose in the tissues and in peptidergic small fibers. Lyftogt Perineural Injection Treatment™ returns tissue and peptidergic small fiber glucose and acidity levels to normal, eliminating neuropathic pain and reducing neurogenic inflammation, allowing restoration of tissue homeostasis or steady state.

 The protective sheath of the nerve trunk is structurally very similar to tendons and ligaments. It protects all nerves inside the nerve trunks from injury, friction and pressure. Nerve trunks have their own small fiber nerve innervation called ‘Nervi Nervorum’.

When irritated or injured these Nervi Nervorum are responsible for pain and swelling of the protective sheath of the nerve trunk. This was already demonstrated 125 years ago by Professor John Marshall from London and called neuralgia. It is now called ‘neurogenic inflammation’.                                                                                                       

It is also known that this ‘neurogenic inflammation’ differs from other forms of inflammation in that it does not respond to anti-inflammatory drugs or cortisone injections and this is the reason why these commonly used drugs are proving to be ineffective in many painful conditions. In addition, there is a growing awareness that cortisone and anti-inflammatory drugs are associated with a variety of harmful side effects.

 It is clear from clinical observations on more than five thousand patients and large case series that Lyftogt Perineural Injection Treatment™ effectively reverses ‘neurogenic inflammation’ and resolves ‘neuralgia’ and ‘neuropathic’ or chronic pain.

After the success of Lyftogt P.I.T.™ with Achilles tendonitis other persistent painful conditions of the neck, back, shoulders, elbows, wrists, knees, ankles and feet have been effectively treated by targeting the local inflamed and painful superficial nerves with micro- injections with low dose Glucose.

More recently Dr Lyftogt has developed effective P.I.T. treatment protocols for Migraine, ‘Fibromyalgia’, CRPS (Complex Regional Pain Syndrome), compartment syndrome and other difficult to treat persistent painful conditions.

Lyftogt P.I.T.™ is an effective, novel and evolving treatment for non-malignant persistent pain, based on sound neuroscientific principles.

For a practitioner to be effective in treating persistent pain the first requirement is the ability to make an accurate neuro-anatomical diagnosis and secondly combining this diagnosis with training in specialised clinical skills. This knowledge and skill can only be obtained by attending specific workshops in Lyftogt P.I.T.™. Most doctors who have attended these workshops will develop confidence and experience over time. It will allow them to approach most chronic painful conditions with understanding and competence.

The veil surrounding the mystery of persistent pain is lifting in the 21st century.

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10 years of Lyftogt Perineural Injection Treatment workshops!

10 years on, over 50 Introductory workshops and 40 Master Classes have been held in 17 countries.

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